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The interaction between deformable surfaces and oscillatory driving is known to produce complex secondary time-averaged flows due to inertial and elastic nonlinearities. Here, we revisit the problem of oscillatory flow in a cylindrical tube with a deformable wall, and analyse it under a long-wave theory for small deformations, but for arbitrary Womersley numbers. We find that the oscillatory pressure does not vary linearly along the length of a deformable channel, but instead decays exponentially with spatial oscillations. We show that this decay occurs over an elasto-visco-inertial length scale that depends on the material properties of the fluid and the elastic walls, the geometry of the system, and the frequency of the oscillatory flow, but is independent of the amplitude of deformation. Inertial and geometric nonlinearities associated with the elastic deformation of the channel drive a time-averaged secondary flow. We quantify the flow using numerical solutions of the perturbation theory, and gain insight by developing analytic approximations. The theory identifies a complex non-monotonic dependence of the time-averaged flux on the elastic compliance and inertia, including a reversal of the flow. Finally, we show that our analytic theory is in excellent quantitative agreement with the three-dimensional direct numerical simulations of Pandeet al.(Phys. Rev. Fluids, vol. 8, no. 12, 2023, 124102). 

Driving oscillatory flow around an obstacle generates, due to inertial rectification, a steady ‘streaming’ flow that is useful in a host of microfluidic applications. While theory has focused largely on two-dimensional flows, streaming in many practical microfluidic devices is three-dimensional due to confinement. We develop a three-dimensional streaming theory around an obstacle in a microchannel with a Hele-Shaw-like geometry, where one dimension (depth) is much shorter than the other two dimensions. Utilizing inertial lubrication theory, we demonstrate that the time-averaged streaming flow has a three-dimensional structure. Notably, the flow reverses direction across the depth of the channel, which is a feature not observed in less confined streaming set-ups. This feature is confirmed by our experiments of streaming around a cylinder sandwiched in a microchannel. Our theory also predicts that the streaming velocity decays as the inverse cube of the distance from the cylinder, faster than that expected from previous two-dimensional approaches. We verify this velocity decay quantitatively using particle tracking measurements from experiments of streaming around cylinders with different aspect ratios at different driving frequencies. 

We study the coupling between rotation and translation of a submerged cylinder in lubricated contact with a soft elastic substrate. Using numerical solutions and asymptotic theory, we analyze the elastohydrodynamic problem over the entire range of substrate deformations relative to the thickness of the intervening fluid film. We find a strong coupling between the rotation and translation of the cylinder when the surface deformation of the substrate is comparable to the thickness of the lubricating fluid layer. In the limit of large deformations, we show that the bodies are in near-Hertzian contact and cylinder rolls without slip, reminiscent of dry frictional contact. When the surface deformation is small relative to the separation between the surfaces, the coupling persists but is weaker, and the rotation rate scales with the translation speed to the one-third power. We then show how the external application of a torque modifies these behaviors by generating different combinations of rotational and translational motions, including back-spinning and top-spinning states. We demonstrate that these behaviors are robust regardless of whether the elastic substrate is thick or thin relative to the length scales of the flow. 

Flagella and cilia are common features of a wide variety of biological cells and play important roles in locomotion and feeding at the microscale. The beating of flagella is controlled by molecular motors that exert forces along the length of the flagellum and are regulated by a feedback mechanism coupled to the flagella deformation. We develop a three-dimensional (3D) flagellum beating model based on sliding-controlled motor feedback, accounting for both bending and twist, as well as differential bending resistances along and orthogonal to the major bending plane of the flagellum. We show that beating is generated and sustained spontaneously for a sufficiently high motor activity through an instability mechanism. Isotropic bending rigidities in the flagellum lead to 3D helical beating patterns. By contrast, anisotropic flagella present a rich variety of wave-like beating dynamics, including both 3D beating patterns as well as planar beating patterns. We show that the ability to generate nearly planar beating despite the 3D beating machinery requires only a modest degree of bending anisotropy, and is a feature observed in many eukaryotic flagella such as mammalian spermatozoa. 

The dynamics of the wrapping of a charged flexible microfiber around an oppositely charged curved particle immersed in a viscous fluid is investigated. We observe that the wrapping behavior varies with the radius and Young's modulus of the fiber, the radius of the particle, and the ionic strength of the surrounding solution. We find that wrapping is primarily a function of the favorable interaction energy due to electrostatics and the unfavorable deformation energy needed to conform the fiber to the curvature of the particle. We perform an energy balance to predict the critical particle radius for wrapping, finding reasonably good agreement with experimental observations. In addition, we use mathematical modeling and observations of the deflected shape of the free end of the fiber during wrapping to extract a measurement of the Young's modulus of the fiber. We evaluate the accuracy and potential limitations of this in situ measurement when compared to independent mechanical tests. 

Modern inertial microfluidics routinely employs oscillatory flows around localized solid features or microbubbles for controlled, specific manipulation of particles, droplets, and cells. It is shown that theories of inertial effects that have been state of the art for decades miss major contributions and strongly underestimate forces on small suspended objects in a range of practically relevant conditions. An analytical approach is presented that derives a complete set of inertial forces and quantifies them in closed form as easy-to-use equations of motion, spanning the entire range from viscous to inviscid flows. The theory predicts additional attractive contributions toward oscillating boundaries, even for density-matched particles, a previously unexplained experimental observation. The accuracy of the theory is demonstrated against full-scale, three-dimensional direct numerical simulations throughout its range. 

Classical diffusiophoresis describes the motion of particles in an electrolyte or non-electrolyte solution with an imposed concentration gradient. We investigate the autophoresis of two particles in an electrolyte solution where the concentration gradient is produced by either adsorption or desorption of ions at the particle surfaces. We find that when the sorption fluxes are large, the ion concentration near the particle surfaces, and consequently the Debye length, is strongly modified, resulting in a nonlinear dependence of the phoretic speed on the sorption flux. In particular, we show that the phoretic velocity saturates at a finite value for large desorption fluxes, but depends superlinearly on the flux for adsorption fluxes, where both conclusions are in contrast with previous results that predict a linear relationship between autophoretic velocity and sorption flux. Our theory can also be applied to precipitation/dissolution and other surface chemical processes.